Built during the reign of Constantine the Great (4th Century), Mediana is now a protected archeological site. The inhabitants of Roman Naissus apparently settled not only in the core of the city but also its surroundings. Thus it has become clear that Mediana represented an important epicentre of distribution, supplying goods and basic food products for the empire.

Located on what was then 'Via militaris' (military road), now the Niš - Sofia road, the estate occupies 40 hectares and exhibits the remnants of a granary, craft centre, villas, thermae, and the remains of an ancient villa with rich mosaics, most of which depict geometrical or floral motifs. The museum contains sculptures and portraits of Roman gods and goddesses, utensils for daily use (bowls, pitchers, lamps) and lead pipes used to provide healing hot water from the nearby Niška Banja (Niš Spa). The Roman emperor obviously prized his luxury. Well worth seeing in the summer months to fully feel the spirit of Constantine's relaxing retreat.