Although it is not possible to provide an exact date for its founding, the history of the church is intertwined with that of the knightly Order of the Holy Sepulchre, which established their headquarters here. The Order was active in Cagliari as early as the 16th century and its main mission was to provide burial to the poor. The main entrance to the church is on its right-hand side, which gives onto the square. The church has a single nave with side chapels. The altar in Our Lady of Mercy Chapel is actually one of the finest examples of the Baroque style in Cagliari. Thanks to restoration works in the 1980s, the sepulchral crypt is also open to visitors.